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John Wiley & Sons, 2012.

Additionally, serum levels of short-chain fatty acids (SCFAs), vital bacterial metabolites produced in the colon, are lower in elderly individuals (Sanna et al., 2019)

Taken together, during RA, macrophages produce proinflammatory cytokines, chemokines, and free radicals to activate immune and non-immune cells, leading to joint inflammation and destruction