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Toxic Mechanism: From an anticonvulsant mechanism it simply increases levels of GABA

Clin Ther 2003;25:1429-39 87 -Plioplys AV ea

Physiological values of ROS are required to sustain the signaling pathways controlling crucial cellular processes, among which are inflammation, differentiation, proliferation, homeostasis, and apoptosis, whereas the generation of dysregulated ROS can amplify these same pathways, thus fostering disease phenotypes associated with ROS, as seen in type II diabetes, cancer, and atherosclerosis [19]