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Iron participates in glutamate synthesis through activating cytosolic aconitase, while glutamate enhances cellular iron uptake capacity by upregulating the expression of divalent metal transporter 1 (DMT1)

1 Years earlier, in the search for compounds that are selectively lethal to RAS-mutated tumor cells, researchers already identified two structurally independent small molecules named erastin and RSL3 that were able to induce a unique form of cell death

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If the injection contains semaglutide or tirzepatide, patients with a personal or family history of medullary thyroid cancer or multiple endocrine neoplasia type 2 should not receive it