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In both pathways, cysteine-dependent proteases known as caspases execute apoptotic cell death by cleaving key structural and regulatory proteins, primarily through the action of caspase-3 (CASP3) and caspase-7 (CASP7), with caspase-6 (CASP6) contributing to downstream substrate cleavage and apoptotic progression

is thought to result from insults that include tissue hypoxia

In another case series, patients with elevated donor liver ferritin levels exhibited a 30% increased risk of developing hepatocyte necrosis in the early postoperative period compared to those with normal levels

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