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Gallicchio MA, McRobert EA, Tikoo A, Cooper ME, Bach LA

[0432] In certain embodiments, the anti-ALPP/ALPPL2 antibodies described herein {e.g., M25ADLF, M25ADLFEG, M25ADLFDS, M25FYIA, M25FYIAEG, M25FYIADS, M25, M25EG, M25DS, M25AELF, M25AELFEG, M25AELFDS, M25ADL99P, M25ADL99G, M25ADS95R, M25ADD28G, M25ADS91G, M25ADY93H, M25ADYHSRLF, M25GRITSGFYGDwtLC, M25FSITSGFYGDwtLC, M253018IA, M253018LF, M25AD, M25ADX, ALPPL2rd3_l, ALPPL2rd3_2, M25AGIA, M25AGLF, M25ASIA, M25ASLF, M25ASwt, M25AVIA, M25AVLF, M25ALIA, M25ALLF, M25wtIA, and/or M25wtLF) can be chemically conjugated to the effector molecule (e.g., a cytotoxin, a label, a ligand, a drug, a liposome, etc.)

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Water-Water and Asc-GSH Cycle The water-water cycle begins by reducing the ground state of molecular oxygen to O 2 on the acceptor side of PS I in Mehlers reaction

In vitro treatments of cells and animal experiments were performed randomized