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However it should be noted that prolonged suppression of TSH to about 0.1uU/ml by T4 doses just above physiological in premenopausal women does not appear to induce bone loss, nor is it certain that this therapy increases fracture risk in older women (85)

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[Google Scholar] [9].Zopf D, Ohlson S, Weak-affinity chromatography, Nature 346 (1990) 8788