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The pulse radiolysis studies demonstrated that DSePA-mediated radioprotection of in vitro models was due to its ability to directly scavenge the radiolytically generated hydroxyl and peroxyl radicals [82, 83, 85,86,87]

Subsequently, C1s cleaves C4, generating pro-inflammatory anaphylatoxins C4a and C4b (71)

It is important to mention that although the elderly group receives a small dose of CoQ10, it is administered in conjunction with transcutaneous electrical acupoint stimulation ( In vitro studies have demonstrated that the addition of 50 M CoQ10 to the culture medium resulted in increased expression of Bcl2 and Sirt1 in cumulus cells, and a positive impact on the reduction of ROS, maturation rate, and first polar body extrusion was enhanced from 48.9% to 75.7% by the addition of CoQ10 to the culture medium (Figure 1)