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10.1161/JAHA.116.004328 86 LiuM.HeA.ChuJ.ChenC.ZhangS.HeY.et al (2018b)

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It is noteworthy that this regulatory system has a cross-dialogue with epigenetic mechanismsm 6 A modification can target the regulation of mRNA metabolism of genes associated with histone modification, suggesting that there is a collaborative regulatory network between the epigenome and the epigenome 151,152

The burden of proof lies with the complainant

Here, we review the mechanism of action of cisplatin, the mechanism of resistance to cisplatin, the role of metabolic remodelling in tumorigenesis and development, and the effects of common metabolic pathways on cisplatin resistance