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Protein-bound uremic toxins (IS, pCS, PAGln) accumulate exponentially as eGFR declines below 60 mL/min/1.73 m 2 due to saturable OAT1/3-mediated tubular secretion (113, 167), with patients at eGFR 30 exhibiting 510 higher IS than those at eGFR 90reflecting clearance impairment rather than unique pathogenic mechanisms

This contributed to the development of T2DM [12]

Monomeric L-arginine and L-lysine seem to be good acceptors, while L-alanine, L-serine, L-glutamine, and L-glutamic acids have been reported to be poor acceptors (Lee et al., 2017)

Furthermore, some nutrients such as fat-soluble vitamins improve the flavor and satiety of food significantly

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