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ONA also interfered with the cell-cell interactions that enhance TAMs protumor functions, reducing the secretion of M2 macrophage markers like IL-10 and other tumor-promoting cytokines

Brock CK, Wallin ST, Ruiz OE, Samms KM, Mandal A, Sumner EA, et al

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48 Mitochondrial sirtuins (Sirt3, 4, and 5) In addition to the three nuclear sirtuins (Sirt1, 6, and 7), mitochondrial sirtuins (mtSIRT) include three members, i.e., SIRT3, SIRT4, and SIRT5, which are all involved in regulating stem cell metabolism