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Explored as a possible aid for recovery and lean-mass preservation in frail or catabolic populations, though a Merck-sponsored Phase 2b trial in elderly hip-fracture patients (Adunsky et al., 2011, Archives of Gerontology and Geriatrics, PMID 21067829) was halted early over a cardiac safety signal rather than demonstrating a clear functional benefit

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The data are reported in delta notation relative to the Vienna Pee Dee Belemnite scale (, VPDB), where the stable isotopic composition of oxygen is 18 O = [( 18 O/ 16 O sample ) / ( 18 O/ 16 O standard )] 1 and multiplied by 1000 to give units in permille scaled to a reference (Fig