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Translational PK/PD modeling of tumor growth inhibition and target inhibition to support dose range selection of the LMP7 inhibitor M3258 in relapsed/refractory multiple myeloma

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Lipid peroxidation is implicated in promoting NETs secretion and inhibiting the neutrophil oxidative burst, potentially as a defensive feedback mechanism that allows tumor cells toSREBP to excess oxidative stress

Materials and Methods Reagents and Antibodies All reagents and chemicals used in this study were from Sigma Chemical Company (St