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Although this specific mechanism remains to be directly validated in diabetic kidney disease, it is reasonable to hypothesise that aloe-emodin may exert similar effects given the shared pathological features between diabetic kidney disease and radiation-induced tissue injuryincluding enhanced glycolytic flux, lactic acid accumulation, endoplasmic reticulum stress, mitochondrial dysfunction, and activation of the fibrosis transcriptional programme [14, 16, 17]

2011 May 2;7890

DNA sequencing confirmed the open reading frame in the expression vector

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