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Immune tolerance, embryo implantation, and decidualization are among the physiological functions in the uterus that depend on progesterone-induced autophagy

Studies have demonstrated that microneedle-mediated administration of tacrolimus, tofacitinib, or -MSH achieves superior repigmentation compared to conventional topical or systemic routes, while reducing systemic exposure and associated risks like immunosuppression (141)

PLoS One 12:e0185854

Mature fiber cells do not synthesize proteins and must deal with the consequences of molecular senescence without the capacity for repair