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TB500 has been evaluated in animal models, typically at doses of 250500 mcg per injection or 6 mg/kg body weight , administered multiple times weekly

Chugh R, Sangwan V, Patil SP, Dudeja V, Dawra RK, Banerjee S, Schumacher RJ, Blazar BR, Georg GI, Vickers SM, Saluja AK (2012) A preclinical evaluation of Minnelide as a therapeutic agent against pancreatic cancer

Rizo JA, Spencer TE, Kelleher AM (2024) Protocol for the establishment and characterization of an endometrial-derived epithelial organoid and stromal cell co-culture system

Although the disease usually does not affect the patients intellect or senses at early stage, it may eventually lead to generalized paralysis, the impairment of multiple nervous systems and the loss of respiratory function

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