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however, the three-fold increase in ROS levels most a substantial change compared to what might be considered baseline or typical fluctuations in many other cell types or developmental stages

10.3390/life9010013 Life 24 ManevichY.FeinsteinS

For instance, Borgenvik et al

Figure 6-3 A , C , Relative expression (fold change compared with CON) of selected genes ( A ) and genes related to IGF-1 signaling in the hippocampus on P9 analyzed by qPCR ( C )