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Acknowledgements The authors would like to express their sincere gratitude to the Department of Applied Genetics, Karnatak University, Dharwad, for providing necessary support and resources that made this review possible

Preventive role of metformin on peripheral neuropathy induced by diabetes

Additionally, FSP1 functions independently of glutathione, producing metabolites that trap free radicals, thereby suppressing ferroptosis [20, 21]

The following themes summarize key areas of ongoing investigation: N NMT, NAD , and Energy Metabolism NNMT catalyzes the methylation of nicotinamide, diverting potential NAD precursors into alternative metabolites