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Subjects without presence of another disease that could significantly affect patient immune response were also enrolled as healthy controls

Materials and methods Heart tissue homogenates In this study, remaining cardiac tissue homogenates obtained under the National Science Centre Poland project number 2019/33/N/NZ3/01649 approved by the Ethics Committee for Experiments on Animals at the Ludwik Hirszfeld Institute of Immunology and Experimental Therapy Polish Academy of Sciences, Wroclaw, Poland (Resolution 002/2020 of 15th January 2020) were used

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It serves as a foundational model for the molecular design of target-sensing inhibitors without requiring detailed fine-tuning with target-specific data