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A 2025 study in Biomolecules found that NNMT inhibitor treatment "reduces body weight, white adipose tissue mass, total cholesterol, and adipocyte size in obese mice." These changes suggest cardiovascular benefit beyond simple weight loss

studies have shown that in a resting state, the GSH: GSSG ratio exceeds 100:1, while under oxidative stress, this ratio can decrease to 10:1 or lower

Data availability The RNA-seq data generated in this study has been deposited in the Gene Expression Omnibus (GEO) database at NCBI under accession code GSE249592

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Matrixyl 3000 operates as pure matrikine signaling: one peptide drives collagen synthesis, the other reduces inflammatory IL-6