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CW: Software, Writing original draft, Writing review and editing

Anti-inflammatory polyoxygenated steroids from the soft coral Lobophytum michaelae

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In particular, Trastuzumab emtansine (Kadcyla, T-DM1) that comprises an HER2-targeted antibody, a non-cleavable linker and a microtubule disrupting agent as the payload, and Trastuzumab deruxtecan (Enhertu, T-DXd), which is composed of a HER2-targeted antibody, a cleavable linker and a Topoisomerase I inhibitor as payload

After blocking with 5% nonfat dry milk in TBS-Tween for 12 h at room temperature, blots were incubated with appropriate primary antibodies overnight at 4 C