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doi: 10.1158/2326-6066.CIR-23-1105 36 ChenJZhangMLiuYZhaoSWangYWangMet al

Labs use methods like the Paglia and Valentine assay, where samples react with substrates like cumene hydroperoxide, and NADPH consumption is tracked spectrophotometrically

The mechanism behind the selective action of (S)-crizotinib involves the formation of hydrogen bonds with fewer amino acid residues in the MTH1 active pocket