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For the peptides direct action, no

Ensure its not prone to freezing in the back, and use a thermometer to periodically check its accuracy

10.1073/pnas.1404651111 47 DeguchiK.TakaishiM.HayashiT.OohiraA.NagotaniS.LiF.et al (2005)

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Bacteria: Bacterial levels are a delicate balance and can be influenced by several factors including, but not limited to: Route of birth (with vaginally born babies expressing higher diversity versus those born Cesarean) Means of feedings as baby (breast versus formula) Exposures to medications throughout life (antibiotics, antacids, NSAIDS, steroids, etc.) Stress (as stress hormones can alter intestinal lining integrity and affect peristaltic rate) Trauma Diet (more on this later!) Nutrient levels Alcohol & drug use Toxic exposure (pesticides, pollution) Nutritionally speaking, one of the best predictors of good health is the inclusion and diversification of fibers