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3p), likely as a result of the inhibition of lysosomal acid lipase 32 , degrading TGs and CE to FAs and cholesterol, by the CQ-mediated alkalinization of the lysosomes 33

Such mechanisms contribute to the formation of iron-rich mitochondrial complexes around erythroblast nuclei instead of the standard incorporation of iron into PPIX in the mitochondria [92]

Sadeghpour S, Ghasemnejad-Berenji M, Maleki F, Behroozi-Lak T, Bahadori R, Ghasemnejad-Berenji H

Interestingly, among T2D subjects, MetALD subjects had the highest prevalence of CVE, suggesting that the interplay between T2D and increased alcohol intake could increase the risk of CVE

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