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FIZZ, Found in Inflammatory Zone

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During aging, the JAK-STAT signaling pathway is dysregulated, contributing to immunosenescence by driving persistent inflammation and altering immune cell function

Given that PON1 levels may vary according to genetic background, assay conditions, and disease severity, external validation is essential to confirm the generalizability and clinical utility of this threshold

The commonly used biopsy technique comprises fine needle aspiration (FNA), excisional biopsy, and core needle biopsy, with core needle being the preferred one because of its capability to preserve tissue architecture and facilitate receptor testing (191)