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Crizotinib (PF-02341066) as a potent inhibitor of c-Met and ALK received approval for the treatment of patients with locally advanced or metastatic NSCLC that is ALK-positive in 2013 [70]

FY22 SBIR Program Summary Agency Dollars Obligated % Total DOD 2,145,738,302 52.134 % DOE 337,322,776 8.196 % NSF 202,553,284 4.921 % NASA 189,474,131 4.604 % USDA 34,738,810 0.844 % DHS 17,032,004 0.414 % DOC 14,398,941 0.350 % DOT 13,856,714 0.337 % ED 13,094,281 0.318 % EPA 7,290,965 0.177 % HHS 1,140,312,654 27.706 % Total $4,115,812,862 See more details at 2022 SBIR and STTR Annual Report on sbir.gov

Then the animals received an intraperitoneal injection of saline (100 mL/kg) and were placed in individual cages for recovery

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