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At present, THC-containing products are registered treatments for chemotherapy-induced nausea and vomiting, and spasticity associated with multiple sclerosis, whereas CBD is a registered drug to treat intractable epilepsies such as Dravet syndrome and Lennox-Gastaut syndrome [20, 21]

Although modulating endothelium-derived vasoactive factors, antioxidation and regulating programmed cell death are beneficial for improving CC endothelial dysfunction related to MetS, limited literature evidence, low bioavailability, lack of cell specificity and low clinical efficacy as well as other factors have restricted the drug development based on these targets

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The microtubule-associated protein Tau ( MAPT ) gene, which is involved in stabilization of cytoskeleton and subsequent facilitation of the transport of neurotransmitters, has also been found as a locus associated with genetic risk for PD (Satake et al., 2009)