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When side effects do occur, they are typically mild and may include: Mild gastrointestinal symptoms such as nausea, diarrhoea, or upset stomach, particularly when starting supplementation or taking high doses on an empty stomach Skin reactions including itching, rash, or a sensation of swelling, though these are uncommon Headache or dizziness in some individuals, particularly with intramuscular injections Injection site reactions (pain, redness, or swelling) when B12 is administered via intramuscular injection for deficiency treatment It is important to note that serious adverse effects are rare

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Estimated Number of MIPS Eligible Clinicians in the CY 2025 Performance Period/2027 MIPS Payment Year (1) Initial Population of Clinicians Included in the RIA Baseline and Proposed Policies Models For this final rule, we applied the same assumptions as in the CY 2024 PFS final rule (88 FR 79505) to estimate our initial population of clinicians based on CY 2022 performance period/2024 MIPS payment year data