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Molecular testing and/or functional studies (which test carnitine uptake in cell culture) allow for confirmation of Carnitine Deficiency Syndrome diagnosis The treatment of Carnitine Deficiency Syndrome involves administration of carnitine supplements and symptomatic treatment, along-with lifestyle changes and dietary control

In biotin deficiency, metabolic disturbances and immune dysfunction can occur (62)

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Meanwhile, supplementation with carnitine (approximately 36 g/day) has been reported to have potential benefits in some studies e.g., it has been claimed to improve mental dysfunction in older adults with early Alzheimers disease (Montgomery et al., 2003)

10.1016/j.cmet.2019.08.021 27 ChenY.WangM