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These findings support the safety and potential disease-modifying effects of FUS-mediated BBB opening in early-stage AD, although larger trials are warranted to establish clinical efficacy (Rezai et al., 2024)

Chondrocytes are involved in maintaining the integrity of the extracellular matrix and controlling the balance of articular cartilage homeostasis, thereby contributing to the deceleration of OA development (158, 159)

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