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doi: 10.1186/s13287-022-03147-w 10 FerrariL

In sum, UA orchestrates diverse anti-cancer mechanisms from reconfiguring the tumor immune landscape and reversing multidrug resistance to provoking autophagy, and ferroptosis-driven cell death

IECs derived from the lesional small intestinal mucosa of CD patients exhibited decreased expression of GPX4, which was paralleled by decreased enzymatic activity (Fig