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High doses of glutathione, particularly through injections, may lead to reduced melanin levels, which can result in white or grey hair as a side effect of skin whitening treatments

It is a substrate for -ketoglutarate dehydrogenase (OGDH) in oxidative reactions generating succinyl-CoA and isocitrate dehydrogenase 1 (IDH1) or isocitrate dehydrogenase 2 (IDH2), which catalyze the reductive carboxylation reaction converting -KG to isocitrate

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Others who may not be able to tolerate dosages of vitamin B12 that are higher than what is found in most multivitamins include people who have been diagnosed with low potassium, Leber's vision loss, or atrophic gastritis, according to WebMD