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Future research priorities should include the design and execution of adequately powered, controlled clinical trials that systematically account for interspecies pharmacokinetic variation, disease stage, comorbid conditions, and potential breed-specific metabolic differences

To provide further support for these findings, we employed another STING agonist (SR717) at concentrations of 1, 2, 4, 8, and 10 M for 24 h in Caco-2 cells

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Patient heterogeneity further complicates translation: HFpEF is frequently associated with systemic metabolic dysfunction, whereas HFrEF often reflects ischemic or toxic injury

In addition to activating T cells, DCs also promote tolerance by influencing regulatory T cells (Treg)