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These trends support the interpretation of statistically significant biochemical shifts as modulation of metabolic processes rather than clinically adverse events

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The success of the Shared Savings Program notwithstanding, we explained in the CY 2025 PFS proposed rule (89 FR 61852) that targeting a subset of beneficiaries with specific diseases or conditions who received care from entities participating in certain disease- or condition-specific models and allowing them to more easily align to those entities will lead to better care and outcomes