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Secondly, in terms of cytokine network regulation, TMAO can promote the secretion of pro-inflammatory factors such as IL-6 and IL-12p40 by DCs, while inhibiting the production of anti-inflammatory factor IL-10

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The viral hijack of human ACE2 receptor disrupts RAAS activation, upregulates NF-B pathway and the ensuing cytokine storm, hypertension, cell proliferation, inflammation, and fibrosis elicits detrimental effects on every bodily organ, the CV system, in particular 635

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doi: 10.1093/eurheartj/ehx342