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BSO-mediated activation of NF-kappaB leads to multiple cell-protective responses, such as the trans-activation of heat shock protein 27, which stops the apoptotic signal after Bax translocation and cytochrome c release (Filomeni et al., 2005), and the main anti-apoptotic protein Bcl-2

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Metformin, compound C (dorsomorphin), and erastin were purchased from Selleck Chemicals, Yuanye Biotechnology, and MedChemExpress, respectively

A history of other substance use, higher socioeconomic status, or exposure to family violence or substance abuse has also been reported more often in this population (37, 38)

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