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For these reasons, any in vitro or in vivo model of CF utilized for the study of oxidative stress or its implication in the disease pathogenesis, should be first characterized with the most appropriate techniques proposed in the following sections

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SURF1 mutation is the other most studied COX deficiencies resulting in LS and other metabolic disorders

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Recent research advances have confirmed the existence of different ISCs in enzymes that regulate DNA metabolism, including helicases, nucleases, primases, DNA polymerases, and glycosylases

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Gill MW, Schatz RA (1985) The effect of diazepam on brain levels of S-adenosyl-L-methionine and S-adenosyl-L-homocysteine: possible correlation with protection from methionine sulfoximine seizures

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