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performed a metabolism study with bromfenac to scrutinize the formation of reactive intermediates and their linkage to the hepatotoxicity of this compound ( In vitro studies have revealed that bromfenac requires conjugation by UGTs to form a bromfenac glucuronide intermediate that cyclizes to a major metabolite, bromfenac indolinone (BI)

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Mechanistic investigations of the mitochondrial complex I inhibitor rotenone in the context of Pharmacological and safety evaluation