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The oral formulation of semaglutide (Rybelsus) is the only GLP-1 medication that does not require refrigeration at all

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However, the level of response varied between species

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Hu Q, Zhang Y, Lou H, Ou Z, Liu J, Duan W, et al

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In a methicillin-resistant Staphylococcus aureus (MRSA) infection model, mice treated with spermidine exhibited significantly improved survival rates and enhanced bacterial clearance, providing robust experimental evidence for spermidines potential application in treating infectious diseases and laying the groundwork for its clinical use as an immunomodulator (116)

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