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RAS-blocking bisphosphonate zoledronic acid inhibits the abnormal proliferation and differentiation of juvenile myelomonocytic leukemia cells in vitro

APT: activation, proliferation and transformation

Liposomal formulations show modest improvements but still fall far below IV-achievable levels

Discussion Sm TGR crystals were previously obtained by other authors, revealing important structural characteristics of the enzyme, such as the fusion of both Grx and TrxR domains and the precise location of the huge clefts (herein defined by P0 and P1 from the DogSite analysis) that harbor the FAD molecules 28

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