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A follow-up study in 31 of these women found that taking 5 grams of collagen daily for a total of 4 years was associated with a progressive increase in BMD

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This makes sense biologically

Remarkably, gene expression profiling studies have shown that GHK-Cu treatment can shift aged fibroblasts toward more youthful gene expression patterns, reversing age-related changes in gene activity related to collagen production, matrix remodeling, inflammatory responses, and cellular senescence

But mitochondria can also sense danger when cell energy levels drop and are involved in sending the final message when a cell is damaged beyond repair and needs to die