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Disruption of GSH production can impair tumorigenesis 17,18,19 , but the exact mechanisms involved are unclear

doi: 10.1016/j.tiv.2009.07.036

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showed that, in a microenvironment deprived of glutamine, due to glutamine addiction in clear cell renal cell carcinoma (ccRCC), tumor-associated macrophages (TAMs) promote an immunosuppressive microenvironment [154]