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Antioxidant and Tissue Protection Copper is required for the function of several key antioxidant enzymes, including superoxide dismutase

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In this disease, absence of digestive enzymes and intrinsic factors has occurred

Additionally, the nuclear transcription factor (Foxo1) is phosphorylated upon activation of phosphoinositide- 3-kinaseprotein kinase B/Akt (PI3 K-PKB/Akt), which in turn deactivates molecules to restrict the activity of proapoptotic pathways [66]

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