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However, other conditions can also cause white spots

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The ensuing pathology, largely consisting of macrophage and lymphocyte infiltration of mainly the spinal cord, recapitulates the inflammatory pathology of acute MS lesions in a number of respects, but differs from MS in important ways: many EAE variants exhibit only limited demyelination confined to the spinal cord white matter, contrasting with extensive brain pathology also prominently affecting cortical gray matter in MS

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(2016) reviewed 54 studies and found that prolotherapy consistently reduced pain and improved function in various ligament injuries