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The study of drug metabolism is one of the tenets of pharmacokinetics (PK) as metabolism (M), the fourth stage of LADME (a drug's transit through the body), involves the enzymatic biotransformation and non-enzymatic biotransformation of a drug, thereby leading to the fifth stage, excretion (E)

Pixel quantification of images was achieved using Image J and statistics were performed using Prism 5 and InStat v.3.05

Collectively, these findings raise the possibility that the mechanism of glucocorticoids increasing serum IGF-I levels is by directly inducing post-IGF-IR signaling resistance

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