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Description

In patients with Leber's disease, administration of cyanocobalamin may cause acute and rapid atrophy of the optic nerve

Most success stories come from real-world experiences rather than large clinical trials

Collectively, these findings support the potential use of CCL11 mRNA levels or promoter methylation patterns as biomarkers for VCD in long COVID

Perhaps they were imprecise and unsuccessful

There are no other absolute contraindications reported for hydroxocobalamin use in deficiency states, but caution is advised in individuals with conditions such as early Lebers optic neuropathy (a rare hereditary optic atrophy) due to the theoretical risk of worsening vision