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Efforts to enhance antioxidant properties through molecular modifications, using advanced technologies such as prodrug strategies, nanotechnology, polymer complexation, targeted delivery systems, or conversion into inhalable formulations, have yielded variable success

Proc Natl Acad Sci USA 102 , 1349613501 (2005)

Inhibition of glutaminolysis by Gln depletion, by chemical inhibition of the critical regulators of Gln metabolism such as GLS and MYC, or genetic knockdown of these genes and Gln transporters resulted in the inhibition of the essential CSC-driving signaling mechanisms (e.g., WNT/-catenin

This is clearly demonstrated by experiments in which the administration of the neurotoxin MPTP, which blocks Complex I of the mitochondrial electron transport chain, induces characteristic features of PD in mice [56, 57]