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Biomaterials 27, 497504

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Figure 1 Regulatory mechanism (Figure 1): The essence of ferroptosis lies in the depletion of glutathione (GSH) and the decline in the activity of glutathione peroxidase (GPX4), which leads to a reduction in the amount of glutathione reductase catalyzed by GPX4 and excessive accumulation of lipid peroxides (10)

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