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DCM/HF pathological model was induced through the intraperitoneal administration of Dox at 2 mg/kg twice a week (Monday and Friday), for 52 days as described (Hayward and Hydock, 2007) (Figure 1)

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590,592,593 By calculating flux control ratiosratios of oxygen flux under different respiratory control conditionsthe SUIT protocol enables internal normalization, facilitating comparisons across different studies