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reactivation of STK11 (serine/threonine kinase)/AMPK pathway was required for excessive mitochondrial fission and lethal mitophagy [153]

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Research has shown that isoflavones and flavonoids of BP restrain the cell cycle at G1 and or G2/M stages and upregulate the expression of pro-apoptotic genes and dysfunction of the capability of enzymes associated with the growth and development of tumor cells while hindering the activity of intermediates such as fibroblast growth factor (FGF) and vascular endothelial growth factor (VEGF) and also inhibiting the production of ROS (177, 178)

Thus, maintenance of CD38 expression is likely important for continued responsiveness of MM cells to anti-CD38 therapy

Qifu-yin activates the Keap1/Nrf2/ARE signaling and ameliorates synaptic injury and oxidative stress in APP/PS1 mice