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Tomko RL, Baker NL, Hood CO, Gilmore AK, McClure EA, Squeglia LM, et al

A double-blind, placebo-controlled randomized trial of skin-lightening cream containing lycopene and wheat bran extract on melasma

For det andet reducerer det ekspressionen af metalloproteinaser der nedbryder kollagen, og ger ekspressionen af TIMP (tissue inhibitor of metalloproteinases) der hmmer denne nedbrydning